There is something similar in Luke, 10:3, perhaps indicating a Q source. This is another admonition to his apostles. Jesus was going to send them out (Ἰδοὺ ἐγὼ ἀποστέλλω ὑμᾶς) like sheep in the middle of wolves (ὡς πρόβατα ἐν μέσῳ λύκων). Thus, they had to be as wise, intelligent, shrewd, or sensible as serpents (γίνεσθε οὖν φρόνιμοι ὡς οἱ ὄφεις). They had to be as innocent, simple, unsophisticated, sincere, or blameless, as doves (καὶ ἀκέραιοι ὡς αἱ περιστεραί). This was a tall order with this dichotomous speech.
The officials of Jerusalem were like the princes of Jerusalem. However, these city officials were like wolves instead of lions, seeking their prey. They too destroyed lives and shed blood. They had hoped to get some dishonest gain from these activities.